Moreno, a Houston performer, artisan, and administrator, replaces Shayna Schlosberg.
The lineup includes work by Suzan-Lori Parks, Maria-Irene Fornes, Clare Barron, and Will Eno, as well as a new musical from Tamarie Cooper.
The slate will include three world premieres, a Mickle Maher mini-festival, and an immersive show.
The Houston theatre sets five plays for its 10th season.
This small performance space has built a cult-like following for its in-your-face aesthetic and pay-as-you-can ticketing policy.